来氟米特通过抑制T细胞延长协调性异种心脏移植物生存期

Abstract

研究背景：利用大鼠仔鼠到小鼠的异种心脏移植模型，研究来氟米特在协调性异种移植模型中的作用机制。 材料与方法：分别以SPF级和清洁级Lewis/SD大鼠仔鼠为供体，C57BL/6或Balb/c小鼠为受体行颈部异位心脏移植，观察其生存期。再以SD大鼠仔鼠为供体，C57BL/6小鼠为受体行颈部异位心脏移植，并分为两组：对照组不予抗排斥药物治疗，实验组予以来氟米特单药治疗(30mg/Kg·d)。观察两组移植物生存期，在术后第6天采集移植物、受体血清、受体脾细胞进行检测。最后以Balb/c小鼠为供体，C57BL/6小鼠为受体行同种移植，并分为两组：对照组不予抗排斥药物治疗，实验组予以来氟米特单药治疗(...Background: The mechanism of leflunomide in concordant xenotransplantation was studied in a rat to mouse xenograft model. Materials and methods: SPF-grade and cleaner-grade Lewis/SD rats were used as donors, and C57BL/6 or Balb/c mice were used as recipients for cervical heterotopic heart transplantation to observe their survival. Then, SD rats and C57BL/6 mice were used as donors and recipients ...